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Manuscripts

Klein C, Grudzien M, Appaswamy G, Germeshausen M, Sandrock I, Schäffer AA, Rathinam C, Botzug K, Schwinzer B, Rezaei N, Bohn G, Melin M, Carlsson G, Fadeel B, Dahl N, Palmblad J, Henter J-I, Zeidler C, Grimbacher B, Welte K (2007) HAX1 deficiency causes autosomal recessive severe congenital neutropenia (Kostmann disease). Nat Genet. 39(1):86-92 Bohn G, Allroth A, Brandes G, Thiel J, Glocker E, Schäffer AA, Rathinam C, Taub N, Teis D, Zeidler C, Dewey RA, Geffers R, Buer J, Huber LA, Welte K, Grimbacher B, Klein C (2007) A novel human primary immunodeficiency syndrome caused by deficiency of the endosomal adaptor protein p14. Nat Med. 13(1):38-45 Sauer M, Zeidler C, Meissner B, Rehe K, Hanke A, Welte K, Lohse P, Sykora KW (2007) Bone Marrow Transplant. [Epub ahead of print] Skokowa J, Germeshausen M, Zeidler C, Welte K (2007) Severe congenital neutropenia: inheritance and pathophysiology. Curr Opin Hematol. 14(1):22-8. Review Germeshausen M, Ballmaier M, Welte K (2007) Incidence of CSF3R mutations in severe congenital neutropenia and relevance for leukemogenesis: Results of a long-term survey. Blood 1;109(1):93-99 Köllner I, Sodeik B, Schreek S, Heyn H, von Neuhoff N, Germeshausen M, Zeidler C, Kruger M, Schlegelberger B, Welte K, Beger C (2006) Mutations in neutrophil elastase causing congenital neutropenia lead to cytoplasmic protein accumulation and induction of the unfolded protein response. Blood 108(2):493-500 Skokowa J, Cario G, Uenalan M, Schambach A, Germeshausen M, Battmer K, Zeidler C, Lehmann U, Eder M, Baum C, Grosschedl R, Stanulla M, Scherr M, Welte K (2006) LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia. Nat Med. 12(10):1191-1197 Hochberg JC, Miron PM, Hay BN, Woda BA, Wang SA, Richert-Przygonska M, Aprikyan AA, Newburger PE (2006) Mosaic tetraploidy and transient GFI1 mutation in a patient with severe chronic neutropenia. Pediatr Blood Cancer. Nov 9; [Epub ahead of print] Alapi K, Erd s M, Kovacs G, Marodi L (2006) Recurrent CXCR4 sequence variation in a girl with WHIM syndrome. Eur J Haematol. 78(1):86-88 Jung J, Bohn G, Allroth A, Boztug K, Brandes G, Sandrock I, Schaffer AA, Rathinam C, Kollner I, Beger C, Schilke R, Welte K, Grimbacher B, Klein C (2006) Identification of a homozygous deletion in the AP3B1 gene causing Hermansky-Pudlak syndrome, type 2. Blood 108(1):362-9 James RM, Kinsey SE (2006) The investigation and management of chronic neutropenia in children. Arch Dis Child. 91(10):852-8. Review Welte K, Zeidler C, Dale DC (2006) Severe congenital neutropenia. Semin Hematol. 43(3):189-95. Review Carlsson G, Wahlin YB, Johansson A, Olsson A, Eriksson T, Claesson R, Hanstrom L, Henter JI (2006) Periodontal disease in patients from the original Kostmann family with severe congenital neutropenia. J Periodontol. 77(4):744-51 Rosenberg PS, Alter BP, Bolyard AA, Bonilla MA, Boxer LA, Cham B, Fier C, Freedman M, Kannourakis G, Kinsey S, Schwinzer B, Zeidler C, Welte K, Dale DC; Severe Chronic Neutropenia International Registry (2006) The incidence of leukemia and mortality from sepsis in patients with severe congenital neutropenia receiving long-term G-CSF therapy. Blood. 107(12):4628-35 Donadieu J, Michel G, Merlin E, Bordigoni P, Monteux B, Beaupain B, Leverger G, Laporte JP, Hermine O, Buzyn A, Bertrand Y, Casanova JL, Leblanc T, Gluckman E, Fischer A, Stephan JL (2005) Hematopoietic stem cell transplantation for Shwachman-Diamond syndrome: experience of the French neutropenia registry. Bone Marrow Transplant. 36(9):787-92 Donadieu J, Leblanc T, Bader Meunier B, Barkaoui M, Fenneteau O, Bertrand Y, Maier-Redelsperger M, Micheau M, Stephan JL, Phillipe N, Bordigoni P, Babin-Boilletot A, Bensaid P, Manel AM, Vilmer E, Thuret I, Blanche S, Gluckman E, Fischer A, Mechinaud F, Joly B, Lamy T, Hermine O, Cassinat B, Bellanne-Chantelot C, Chomienne C (2005) French Severe Chronic Neutropenia Study Group. Analysis of risk factors for myelodysplasias, leukemias and death from infection among patients with congenital neutropenia. Experience of the French Severe Chronic Neutropenia Study Group. Haematologica 90(1):45-53 Germeshausen M, Schulze H, Kratz C, Wilkens L, Repp R, Shannon K, Welte K, Ballmaier M (2005) An acquired G-CSF receptor mutation results in increased proliferation of CMML cells from a patient with severe congenital neutropenia. Leukemia. 19(4):611-7 Ferry C, Ouachee M, Leblanc T, Michel G, Notz-Carrere A, Tabrizi R, Flood T, Lutz P, Fischer A, Gluckman E, Donadieu J (2005) Hematopoietic stem cell transplantation in severe congenital neutropenia: experience of the French SCN register. Bone Marrow Transplant. 35(1):45-50 Cotter M, Gulmann C, Jeffers M, Smith OP (2004) Increased bone marrow angiogenesis in children with severe chronic neutropenia treated with granulocyte colony-stimulating factor. J Pediatr Hematol Oncol. 26(8):504-6 Zeidler C, Schwinzer B, Welte K. (2004) Congenital neutropenias. Rev Clin Exp Hematol. 7(1):72-83 Review Carlsson G, Aprikyan AG, Tehranchi R, Dale DC, Porwit A, Hellström-Lindberg E, Palmblad J, Henter J-I, Fadeel B (2004) Kostmann syndrome: severe congenital neutropenia associated with defective expression of Bcl-2, constitutive mitochondrial release of cytochrome с, and excessive apoptosis of myeloid progenitor cells. Blood 103:3355-3361 Carlsson G, Åhlin A, Dahllöf G, Elinder G, Henter J-I, Palmblad J (2004) Efficacy and safety of two different rG-CSF preparations in the treatment of patients with severe chronic neutropenia. Br J Haematology 126:127-132 Papadaki HA, Eliopoulos GD (2003) The role of apoptosis in the pathophysiology of chronic neutropenias associated with bone marrow failure. Cell Cycle. 2(5):447-51 Review Stein SM, Dale DC (2003) Molecular basis and therapy of disorders associated with chronic neutropenia. Curr Allergy Asthma Rep. 3(5):385-8 Review Dale DC, Cottle TE, Fier CJ, Bolyard AA, Bonilla MA, Boxer LA, Cham B, Freedman MH, Kannourakis G, Kinsey SE, Davis R, Scarlata D, Schwinzer B, Zeidler C, Welte K (2003) Severe chronic neutropenia: treatment and follow-up of patients in the Severe Chronic Neutropenia International Registry. Am J Hematol. 72(2):82-93. Review Freedman MH, Alter BP. Malignant myeloid transformation in congenital forms of neutropenia. Isr Med Assoc J. 4(11):1011-4 Zeidler C, Welte K (2002) Kostmann Syndrome and severe congenital neutropenia. Sem Hematol. 39(2):82-88 Boxer L, Dale DC (2002) Neutropenia: Causes and consequences. Sem Hematol. 39(2):75-81 Dale DC, Bolyard AA, Aprikyan A (2002) Cyclic neutropenia. Sem Hematol. 39(2):89-94 Smith OP (2002) Shwachman-Diamond syndrome. Sem Hematol. 39(2):95-102 Kannourakis G (2002) Glycogen storage disease. Sem Hematol. 39(2):103-106 Cham B, Bonilla MA, Winkelstein J (2002) Neutropenia associated with primary immunodeficiency syndromes. Sem Hematol. 39(2):107-112 Palmblad JEW, von dem Borne AEGKr (2002) Idiopathic, immune, infectious, and idiosyncratic neutropenias. Sem Hematol. 39(2):113-120 Starkebaum G (2002) Chronic neutropenia associated with autoimmune disease. Sem Hematol. 39(2):121-127 Freedman MH, Alter BP (2002) Risk of myelodysplastic syndrome and acute myeloid leukemia in congenital neutropenias. Sem Hematol. 39(2):128-133 Cottle TE, Fier CJ, Donadieu J, Kinsey SE (2002) Risk and benefit of treatment of severe chronic neutropenia with granulocyte colony-stimulating factor. Sem Hematol. 39(2):134-140 Pütsep K, Carlsson G, Boman HG, Andersson M (2002) Deficiency of antibacterial peptides in patients with morbus Kostmann: an observation study. Lancet 360:1144-1149 Gavrikova N, Zeidler C, Stanulla M, Germeshausen M, Schwinzer B, Welte K (2001) TNF and lymphotoxin-& polymorphisms in patients with severe chronic neutropenia. Int J Hematol. 74:477-478 Schiller M, Bohm M, Zeidler C, Germeshausen M, Welte K, Luger TA, Bonsmann G (2001) Cyclic neutropenia. Detection of a mutation in the gene for neutrophil elastase (ELA2). Hautarzt 52(9):790-6 Germeshausen M, Schulze H, Ballmaier M, Zeidler C, Welte K (2001) Mutations in the gene encoding neutrophil elastase (ELA2) are not sufficient to cause the phenotype of congenital neutropenia. Br J Haematol. 115(1):222-4 Tschan CA, Pilz C, Zeidler C, Welte K, Germeshausen M (2001) Time course of increasing numbers of mutations in the granulocyte colony-stimulating factor receptor gene in a patient with congenital neutropenia who developed leukemia. Blood 97:1882-4 Carlsson G, Fasth A (2001) Infantile genetic agranulocytosis, morbus Kostmann: presentation of six cases from the original “Kostmann family” and a review. Acta Paediatr 90:757-764 Dale DC, Liles WC, Garwicz D, Aprikyan AG. Clinical implications of mutations of neutrophil elastase in congenital and cyclic neutropenia. Journal of Pediatric Hematology and Oncolocy (in press) Zeidler C, Schwinzer B, Welte K (2000) Severe congenital neutropenia: trends in diagnosis and therapy. Klin Pädiatr. 212(4):145-52 Freedman MH, Bonilla M, Fier C, Bolyard AA, Scarlata D, Boxer LA, Welte K, Brown S, Cham B, Kannourakis G, Kinsey SE, Mori PG, Cottle T, Dale DC (2000) Myelodysplasia syndrome and acute myeloid leukemia in patients with congenital neutropenia receiving G-CSF therapy. Blood 96:429-436 Corbacioglu S, Bux J, König A, Gabrilove JL, Welte K, Bussel JB (2000) Serum granulocyte colony-stimulating factor levels are not increased in patients with autoimmune neutropenia of infancy. J Pediatr 137:96-99 Kasper B, Grothues D, Welte K (2000) Differential expression and regulation of GTPases (RhoA and Rac2) and GDI’s (LyGDI and RhoGDI) in neutrophils from patients with severe congenital neutropenia. Blood 95:2947-2953 Stanulla M, Kasper B, Schrappe M, Viehmann S, Harbott J, Ludwig WD, Welte K (2000) Granulocyte colony-stimulating factor receptor expression and 11q23/MLL genotype in childhood acute lymphoblastic leukemia developing during the first 18 months of life. Leukemia (letter):337-338 Zeidler C, Boxer L, Dale DC, Freedman MH, Kinsey SE, Welte K (2000) Management of Kostmann syndrome in the G-CSF era. Br J Haematol. 109:490-5 Dale DC, Person RE, Bolyard AA, Aprikyan AG, Bos C, Bonilla MA, Boxer LA, Kannourakis G, Zeidler C, Welte K, Benson KF, Horwitz M (2000) Mutations in the gene encoding neutrophil elastase in congenital and cyclic neutropenia. Blood 96(7):2317-22 Zeidler C, Welte K, Barak Y, Barriga F, Bolyard AA, Boxer L, Cornu G, Cowan MJ, Dale DC, Flood T, Freedman M, Gadner H, Mandel H, O'Reilly RJ, Ramenghi U, Reiter A, Skinner R, Vermylen C, Levine JE (2000) Stem cell transplantation in patients with severe congenital neutropenia without evidence of leukemic transformation. Blood 95:1195-8 Freedman MH, Bonilla MA, Fier C, Bolyard AA, Scarlata D, Boxer LA, Brown S, Cham B, Kannourakis G, Kinsey SE, Mori PG, Cottle T, Welte K, Dale DC (2000) Myelodysplasia syndrome and acute myeloid leukaemia in patients with congenital neutropenia receiving G-CSF therapy. Blood 96:429-436 Aprikyan AA, Liles WC, Park JR, Mechthild J, Chi EY, Dale DC (2000) Myelokathexis - a congenital disorder of severe neutropenia characterized by accelerated apoptosis and defective expression of bcl-x in neutrophil precursors. Blood 95:320-327 Horwitz M, Benson KF, Person RE, Aprikyan AG, Dale DC (1999) Mutations in ELA2, Encoding Neutrophil Elastase, Define a 21-day Biological Clock in Cyclic Neutropenia. Nat Genet 23:433-436. Baranova K, Stanulla M, Zeidler C, Welte K (1999) Alkaline phosphatase activity in neutrophils from patients with severe congenital neutropenia (Kostmann's syndrome). Int J Hematol. 1999 Dec;70(4):236-40 Bux J, Hofmann C, Welte K (1999) Serum G-CSF levels are not increased in patients with antibody-induced neutropenia unless they are suffering from infectious diseases. Br J Haematol 105:616-617 Kasper B, Tidow N, Welte, K (1999) Association of src-kinase Lyn and non-src-kinase Syk with the granulocyte colony-stimulating factor receptor (G-CSFR) is not abrogated in neutrophils from severe congenital neutropenia patients with point mutations in the G-CSFR mRNA. Internat J Hematol 70:241-247 Tidow N, Kasper B, Welte K (1999) SH2-containing protein tyrosine phospha­ta­ses SHP-1 and SHP-2 are dramatically increased at the protein level in neutrophils from patients with severe congenital neutropenia (Kostmann's syndrome). Exp Hematol 27:1038-1045 Haurie C, Dale DC, Mackey MC (1999) Occurrence of periodic oscillations in the differential blood counts of congenital idiopathic and cyclical neutropenic patients before and during treatment with G-CSF. Exper Hematol 27:40-1-409. Haurie C, Dale DC, Mackey MC. (1998) Cyclical neutropenia and other periodic hematological disorders: A review of mechanisms and mathematical models. Blood 92:2629-2640 Tidow N, Kasper B, Welte K (1998) Clinical implications of G-CSF receptor mutations. Critical Reviews in Oncology/Hematology 28:1-6 Dale D, Fier C, Welte K (1998) Use of Filgrastim (r-metHuG-CSF) in Severe Chronic Neutropenia (Eds: G. Morstyn, T.M. Dexter, M.A. Foote 121-147, Marcel Dekker, Inc. Bux J, Behrens G, Jäeger G, Welte K (1998) Diagnosis and Clinical Course of Autoimmune Neutropenia in Infancy: Analysis of 240 Cases. Blood 91:181-186 Führer M, Burdach S, Ebell W, Gadner H, Haas R, Harbott J, Janka-Schaub G, Klingebiel T, Kremens B, Niemeyer C, Rampf U, Reiter A, Ritter J, Schulz A, Walther U, Zeidler C, Bender-Götze C (1998) Relapse and clonal disease in children with aplastic anemia (AA) after immunosuppressive therapy (IST): the SAA 94 experience. German/Austrian Pediatric Aplastic Anemia Working Group. Klin Pädiatr. 210(4):173-9 Rusthoven JJ, DeVries EGE, Dale DC, Piccart M, Glaspy J (1997) Consensus on the use of neutrophil-stimulating hematopoietic growth factors in clinical practice: An international viewpoint. Intl J Antimicrob 8:263-275 Freedman MH (1997) Safety of long-term administration of granulocyte colony-stimulating factor for severe chronic neutropenia. Current Opinion in Hematology 4: 217-224 Kasper B, Thole HH, Patterson SD, Welte K (1997) Cytosolic proteins from neutrophilic granulocytes: A comparison between patients with severe chronic neutropenia and healthy donors. Electrophoresis 18:142-149 Dong F, Dale DC, Bonilla MA, Freedman M, Fasth A, Neijens HJ, Palmblad J, Briars GL, Carlsson G, Veeerman AJP, Welte K, Löwenberg B and Touw IP (1997) Mutations in the granulocyte colony-stimulating factor receptor gene in patients with severe congenital neutropenia. Leukemia 11:120-125 Tidow N, Pilz C, Kasper B, Welte K (1997) Frequency of Point Mutations in the Gene for the G-CSF Receptor in Patients with Chronic Neutropenia Under­going G-CSF Therapy. 1997 Hematopoietic Stem Cells 15:113-120 Welte K, Riehm H (1997) Granulocyte Colony-Stimulating Factor in Children with Acute Lymphoblastic Leukemia. N Engl J Med: 1320 (letter) Kasper B, Herbst A, Pilz C, Germeshausen M, Tidow N, Hadam MR, Welte K (1997) Severe congenital neutropenia patients with point mutations in the granulocyte colony-stimuating factor (G-CSF) receptor mRNA express a normal G-CSF receptor protein. Blood 90:2839-2853 Tidow N, Welte K (1997) Advances in understanding postreceptor signaling in response to granulocyte colony-stimulating factor. Current Opinion in Hematology 4:171-175 Spiekermann K, Roesler J, Emmendoerffer A, Elsner J, Welte K (1997) Functional features of neutrophils induced by G-CSF and GM-CSF treatment: differential effects and clinical implications. Leukemia 11:466-478 Welte K, Boxer L (1997) Severe chronic neutropenia: Pathophysiology and Therapy. Sem Hematol 34:267-278 Tidow N, Pilz C, Teichmann B, Müller-Brechlin A, Germeshausen M, Kasper B, Rauprich P, Sykora KW, Welte K (1997) Clinical relevance of point muta­tions in the cytoplasmic domain of the granulocyte colony-stimulating factor (G-CSF) receptor gene in patients with severe congenital neutropenia. Blood 89:2369-2375 Yakisan E, Schirg E, Zeidler C, Bishop NJ, Reiter A, Hirt A, Riehm H, Welte K (1997) High incidence of significant bone loss in patients with severe congenital neutropenia (Kostmann's syndrome). J Pediatr 131,592-597 Sievers EL, Dale DC (1996) Non-malignant neutropenia. Blood Reviews 10:95-100 Palmer SE, Stephens K, Dale DC (1996) Genetics, phenotype, and natural history of autosomal dominant cyclic hematopoiesis. Am J Med Gen 66:413-422 Welte K, Dale D for the SCN-International Registry. (1996) Pathophysiology and treatment of severe chronic neutropenia. Ann Hematol 72:158-165 Welte K, Reiter A, Mempel K, Pfetsch M, Schwab G, Schrappe M, Riehm H (1996) A randomised phase III study of the efficacy of granulocyte colony-stimulating factor in children with high-risk acute lymphoblastic leukemia. Blood 87:3143-3150 Welte K, Gabrilove J, Bronchud MH, Platzer E, Morstyn G (1996) Filgrastim (r-metHuG-CSF): the first ten years. Blood 88:1907-1929 Kalra R, Dale DC, Freedman M, Bonilla MA, Weinblatt M, Ganser A, Bowman P, Abish S, Priest J, Oseas RS, Olson, K, Paderanga D, Shannon K. (1995) Monosomy 7 and activating RAS mutations accompany malignant transformation in patients with congenital neutropenia. Blood 86:4579-4586 Dale DC (1995) Hematopoietic growth factors for the treatment of severe chronic neutropenia. Concise Review. Stem Cells 13:94-100 Bonilla M, Dale D, Zeidler C, Last L, Reiter A, Ruggeiro M, Davis M, Koci B, Hammond W, Gillio A, Welte K (1994) Long-term safety of treatment with recombinant human granulocyte colony-stimulating factor (r-metHuG-CSF) in patients with severe congential neutropenias. Br J Hematol. 88:723-730 Zeidler C, Reiter A, Yakisan E, Koci B, Riehm H, Welte K (1993) Langzeitbehand-lung mit rekombinantem humanen Granulozyten-Kolonien stimulierendem Faktor bei Patienten mit schwerer kongenitaler Neutropenie. Klin. Pädiatr. 205(4): 264-271 Zeidler C, Kanz L, Hurkuck F, Rittmann KL, Wildfang I, Kadoya T, Mikayama T, Souza L, Welte K (1992) In vivo effects of interleukin-6 on thrombopoiesis in healthy and irradiated primates. Blood 80(11):2740-5 Elsner J, Roesler, J, Emmendorffer A, Zeidler C, Lohmann-Matthes ML, Welte K (1992) Altered function and surface marker expression of neutrophils induced by rhG-CSF treatment in severe congenital neutropenia. Eur J Haematol. 48(1):10-9 Schroten H, Wendel U, Burdach S, Roesler J, Breidenbach T, Schweitzer S, Zeidler C, Welte K (1991) Colony-stimulating factors for neutropenia in glycogen storage disease Ib. Lancet. 23;337(8743):736-7 Schroten H, Roesler J, Breidenbach T, Wendel U, Elsner J, Schweitzer S, Zeidler C, Burdach S, Lohmann-Matthes ML, Wahn V, Welte K (1991) G-CSF and GM-CSF for treatment of neutropenia in glycogen storage disease type 1b. J Pediatr 119: 748-754 Mempel K, Pietsch T, Menzel T, Zeidler C, Welte K (1991) Increased serum levels of granulocyte colony-stimulating factor in patients with severe congenital neutropenia. Blood 77: 1919-1922 Pietsch, T, Buehrer C, Mempel K, Menzel T, Steffens U, Schrader C, Santos F, Zeidler C, Welte K (1991) Blood mononuclear cells from patients with severe congenital neutropenia are capable of producing granulocyte colony-stimulating factor. Blood 77(6):1234-7 Roesler J, Emmendorffer A, Elsner J, Zeidler C, Lohmann-Matthes M, Welte K (1991) In vitro functions of neutrophils induced by treatment with rh G-CSF in severe congenital neutropenia. Eur J Haematol. 46(2):112-8 Welte K, Zeidler C, Reiter A, Odenwald E, Souza L, Riehm H (1990) Differential effects of granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor in children with severe congenital neutropenia. Blood 75:1056-1063

Book Articles

Zeidler C, Welte K (1999) Severe congenital neutropenias. In: Cytokines in the treatment of hematopoietic failure. Edited by A. Ganser and D. Hoelzer. Marcel Dekker, Inc.: 373-386 Zeidler C, Welte K (1999) Kongenitale Neutropenien. In: Pädiatrische Allergologie und Immunologie. Edited by U. Wahn, R. Seger, V. Wahn. Urban und Fischer: 499-506 Welte K, Zeidler C, Reiter A, Riehm H (1994) Effects of granulocyte colony-stimulating factor in children with severe neutropenia. Acta Haematol Pol. 25(2 Suppl 1):155-62. Review Welte K, Zeidler C, Reiter A, Riehm H (1993) Effects of granulocyte colony-stimulating factor in patients with severe chronic neutropenia. In: New Concepts in Immunodeficiency Diseases. Edited by S. Gupta and C. Griscelli Wiley:355-369 Zeidler C, Kanz L, Hurkuck F, Souza L, Welte K (1990) In vivo Effects of Interleukin-6 on Thrombopoiesis in Primates. In: Cytokines in Hemopoiesis, Oncology, and AIDS II. Edited by M. Freund, H. Link, R.E. Schmidt, K. Welte. Springer-Verlag: 411-416 Zeidler C, Reiter A, Riehm H, Welte K (1990) Effects of granulocyte colony-stimulating factor in children with severe congenital neutropenia. In: Hematopoietic Growth Factors in Clinical Applications. Edited by R. Mertelsmann and F. Herrmann. Marcel Dekker, Inc.: 225-236

Publizierte Abstrakta von Vorträgen und Postern

Germeshausen M, Ballmaier M, Zeidler C, Schulze H, Welte K (2001) Mutations in the gene encoding neutrophil elastase (ELA2) are not sufficient to cause congenital neutropenia. Blood 98(11):440a (abstract # 1844) Germeshausen M, Jakobs S, Zeidler C, Welte K. Update on the G-CSF receptor gene mutations in patients with severe congenital neutropenia (CN) (2001) Blood 98(11):441a (abstract #1847) Bolyard AA, T Cottle, MA Bonilla, L Boxer, B Cham, J Donadieu, C Fier, M Freedman, G Kannourakis, S Kinsey, B Liang, B Schwinzer, C Zeidler, K Welte, DC Dale (2001) Long term treatment of chronic idiopathic neutropenia in women with G-CSF. Blood 98(11):300a (abstract #1265) Zeidler C, PG Barth, MA Bonilla, AA Bolyard, L Boxer, T Cottle, DC Dale, J Donadieu, C Fier, M Freedman, G Kannourakis, S Kinsey, B Liang, B Schwinzer, K Welte, B Cham (2001) Neutropenia in Barth Syndrome: Clinical Course and Treatment of neutropenia. Blood 98(11):300a (abstract #1264) Kannourakis G, Cottle T, Bolyard AA, Bonilla MA, Boxer LA, Cham B, Dale DC, Fier C, Kinsey SE, Liang B, Mori PG, Welte K (2000) Long term follow up on patients with glycogen storage disease 1b and severe chronic neutropenia treated with G-CSF. Blood 96 (11): 294a Melk A, Zeidler C, Welte K, Germeshausen M (2000) Accelerated telomere loss in patients with severe congenital neutropenia (SCN). Blood 96(11): 609a (abstract #2615) Germeshausen M, Schulz H, Ballmaier M, Lang S, Schaper Y, Zeidler C, Welte K (2000) Decreased neutrophil elastase activity in patients with severe congenital neutropenia is not correlated to mutations in ELA2. Blood 96(11):609a (abstract #2614) Zeidler C, Germeshausen M, Aprikyan AG, Touw I, Dale DC, Welte K (2000) Mutations of the G-CSF receptor gene in AML secondary to severe congenital neutropenia. Blood 96(11):501a (abstract #2159) Aprikyan AG, Germeshausen M, Rodger ER, Stein S, Zeidler C, Welte K, Dale DC (2000) The diversity of neutrophil elastase mutations in congenital neutropenia. Blood 96(11):445a (abstract #1915) Boxer L, Fier C, Bolyard AA, Bonilla MA, Brown S, Cham B, Freedman M, Kannourakis G, Kinsey SE, Mori P, Zeidler C, Welte K, Dale DC (2000) Development of glomerulonephritis in patients (pts) with severe chronic neutropenia (SCN). Blood 96(11):298a (abstract #1284) Kinsey SE, Bolyard AA, Bonilla MA, Boxer L, Brown S, Dale DC, Cham B, Fier C, Freedman M, Kannourakis G, Mori P, Welte K, Zeidler C. (1999) Algorithm for the management of Kostmann’s neutropenia based on data from the Severe Chronic Neutropenia International Registry. Blood 94 (10): 174b Horwitz M, Benson K, Person, R, Aprikyan A, Dale, D (1999) The molecular genetic basis of cyclic hematopoiesis. Blood 94 (10):650a Head DR, Boxer LA, Bolyard AA, Dale DC (1999) Morphologic assessment of marrow aspirates in Severe Congenital Neutropenia (CN) fails to predict evolution to myelodysplastic syndrome (MDS) and acute myeloblastic leukemia (AML). Blood 94 (10): 430a Boxer LA, Dale DC, Bonilla MA, Bolyard AA, Cham B, Freedman M, Kannourakis G, Schwinzer B, Fier C, Brown S, Welte, K (1999) Administration of r-metHuG-CSF during pregnancy in patients with severe chronic neutropenia (SCN). Blood 94 (10): 173b Zeidler C, Levine JE, Bolyard AA, Bonilla MA, Boxer L, Brown S, Dale DC, Cham B, Freedman M, Kannourakis G, Kinsey SE, Mori P, Welte K (1999) Outcomes for hematopoietic stem cell transplantation (HSCT) in severe congenital neutropenia (CN). Blood 94 (10):566a (abstract #2528) Kinsey SE, Bolyard AA, Bonilla MA, Boxer L, Brown S, Dale DC, Cham B, Fier C, Freedman M, Kannourakis G, Mori P, Welte K, Zeidler C (1999) Algorithm for the management of Kostmann’s neutropenia based on data from the Severe Chronic Neutropenia International Registry. Blood 94(10):174b (abstract #3955) Tschan CA, Pilz C, Forstmeyer D, Möricke A, Zeidler C, Welte K, Germeshausen M (1999) Time course of increasing numbers of mutations in the granulocyte colony-stimulating factor receptor gene in a patient with congenital neutropenia who developed leukemia. Blood 94(10):47a (abstract #196) Germeshausen M, Tidow N, Pilz C Tschan C, Zeidler C, Welte K (1999) G-CSF receptor mutations in patients with severe congenital neutropenia: Frequency and implications in leukemic development. Blood 94(10):45a (abstract #188) Führer M, Rampf U, Burdacch S, Dörffel V, Ebell W, Friedrich W, Haas R, Klingebiel T, Niemeyer C, Ritter J, Sörensen J, Stollmann-Gibbels B, Walther JU, Zeidler C, Bender-Götze C (1998) Immunosuppressive therapy (IST) and bone marrow transplantation (BMT) for Aplastic Anamia (AA) in children: Results of the study SAA 94. Blood 92(10):156a (abstract #631) Zeidler C, Vogel R, Wyres M, Welte K (1998) Beneficial effects of stem cell factor (SCF) in children with severe congenital neutropenias refractory to G-CSF. Blood 92(10):380a (abstract #1567) Zeidler C, Levine JE, Bolyard AA, Bonilla MA, Boxer L, Brown S, Dale DC, Cham B, Fier C, Freedman M, Kannourakis G, Kinsey SE, Mori P, Welte K (1998) Bone marrow transplantation (BMT) in patients with severe congenital neutropenia refractory to G-CSF. Blood 92 (10):136a (abstract #548) Zeidler C, Vogel R, Wyres M, Welte K (1998) Beneficial effects of stem cell factor (SCF) in children with severe congenital neutropenias refractory to G-CSF. Exp Hematol. 26(8):782 (abstract #366) Boxer L, Mori PG, Bonilla MA, Dale D, Cham B, Kinsey S, Welte K, Fier C, Catalano P, Cottle T, Kannourakis G, Freedman M for the Severe Chronic Neutropenia International Registry (1997) Report on patients with Shwachman-Diamond syndrome with severe chronic neutropenia. Blood 90:182a Welte K, Touw IP for the Severe Chronic Neutropenia International Registry. (1997) G-CSF receptor mutations in patients with severe chronic neutropenia: a step in leukemogenesis? Blood 90:433a Dale DC, Cottle T, Bolyard AA, Fier C, Aitchison R, Bonilla MA, Boxer L, Catalano P, Cham B, Freedman M, Kannourakis G, Kinsey S, Mori P, Welte K for the Severe Chronic Neutropenia International Registry (1997) Long term treatment of chronic idiopathic neutropenia with G-CSF. Blood 90:173a. Dale DC, Cottle T, Bolyard AA, Fier C, Aitchison R, Bonilla MA, Boxer L, Catalano P, Cham B, Freedman M, Kannourakis G, Kinsey SE, Mori P, Zeidler C, Welte K (1997) Long-term treatment of chronic idiopathic neutropenia with G-CSF. Blood 90(10):173a (abstract #763) Kannourakis G, Kurtzberg J, Bonilla MA, Boxer L, Catalano P, Cham B, Fier C, Kinsey S, Marty J, Freedman MH, Mori PG, Thompson B, Dale DC, Welte K (1996) Report on patients with glycogen storage disease 1b with severe chronic neutropenia (SCN) treated with Filgrastim. Blood 88:349a Freedman MH, Bonilla MA, Boxer L, Catalano P, Cham B, Fier C, Kannourakis G, Kinsey S, Mori PG, Shannon K, Touw I, Welte K, Dale DC, for the Severe Chronic Neutropenia International Registry (1996) MDS/AML in patients with severe chronic neutropenia (SCN) receiving G-CSF. Blood 88:448a Davis RL, Cottle T, Bonilla MA, Box L, Catalano P, Cham B, Fier C, Freedman MH, Kannourakis G, Kinsey S, Mori PG, Welte, Dale DC (1996) Growth among patients with severe chronic neutropenia treated with Filgrastim (G-CSF). Fed Clin Res J Invest Med 45:101A Palmer SE, Stephens K, Dale DC. (1996) Anticipation in autosomal dominant cyclic hematopoiesis. Am J Hum Genet 59:A37 Zeidler C, Bux J, Riehm H, Welte K (1996) Clinical course of autoimmune neutropenia in infancy. Exp Hematol.24 (9):1075 (abstract #273) Boxer L, Dale DC, Bonilla MA, Cham B, Freedman M, Kannourakis G, Brown S, Fier C, Welte K. (1995) Administration of r-met Hu G-CSF during pregnancy in patients with severe chronic neutropenia (SCN). Blood 86:508a Dale DC, Cottle T, Bolyard AA, Fier C, Bonilla MA, Boxer L, Brown SL, Cham B, Freedman M, Kannourakis G, Welte K. (1995) Severe chronic neutropenia: Report on treatment and outcome from a new international registry. Blood 86:425a Zeidler C, Reiter A, Yakisan E, Riehm H, Welte K (1994) Langzeitbehandlung mit G-CSF bei Kindern mit schweren kongenitalen Neutropenien. Monatsschrift Kinderheilk 142(8):83 (abstract #354) Dale DC, Bonilla MA, Boxer L, Freedman M, Brown S, Fier C, Welte K. (1994) Development of AML/MDS in a subset of patients (PTS) with severe chronic neutropenia (SCN). Blood 84:518a Kalra R, Dale D, Freedman M, Bonilla MA, Weinblatt M, Ganser A, Bowman P, Abish S, Priest J, Olson K, Paderanga D, Shannon K (1994) Monosomy 7 and activating RAS mutations accompany malignant transformation in patients with congenital neutropenia (CN) treated with recombinant human granulocyte colony stimulating factor (rh-G-CSF). Blood 84(10): 313a Welte K, Zeidler C, Reiter A, Pietsch T, Souza L, Riehm H, (1993) Long-term treatment with recombinant human granulocyte-colony stimulating factor (rhG-CSF) in patients with severe congenital neutropenia. Blood 74(7):154a (abstract #573) Zeidler C, Reiter A, Yakisan E, Koci B, Riehm H, Welte K (1993) Long-term effects of rhG-CSF treatment in patients with severe congenital neutropenia. Ann Hematol. 66:A102 (abstract #110) Roesler J, Elsner J, Zeidler C, Lohmann-Matthes ML, Welte K (1992) Impaired mobilization of cytosolic free calcium in neutrophils from patients with severe congenital neutropenia. Blood 80(10):95a (abstract #371) Freund M, Heussner P, Sandoval M, Kanz L, Zeidler C, Welte K (1991) Granulocyte-colony stimulating factor (G-CSF) fort he treatment of adult patients with chronic idiopathic neutropenia and cyclic neutropenia. Onkologie 14: 43 (abstract #122) Zeidler C, Kanz L, Pietsch T, Boone T, Samal B, Welte K (1991) In vivo regulation of thrombopoiesis by leukemia inhibitory factor (LIF). Klin. Pädiatr. 203:337 (abstract) Zeidler C, Kanz L, Pietsch T, Boone T, Samal B, Welte K (1990) Leukemia inhibitory factor (LIF) induces thrombocytosis in primates. Blood 76(10):174a (abstract #685) Welte K, Zeidler C, Pietsch T, Rösler J, Schweitzer S, Souza L, Riehm H (1990) Correction of neutropenia in children with glykogenosis 1b by treatment with rhG-CSF. Blood 76(10):171a (abstract #675) Mempel K., Zeidler C, Pietsch T, Menzel T, Welte K (1990) In vivo production of granulocyte colony-stimulating factor (G-CSF) in patients with severe congenital neutropenia. Klin. Pädiatr. 202 (4): 296 (abstract) Zeidler C, Hurkuck F, Souza L, Welte K (1990) Interleukin-6 regulates thrombopoiesis in primates. Klin. Pädiatr. 202 (4): 296 (abstract) Zeidler C, Souza L, Welte K (1990) In vivo effects of interleukin-6 on hematopoiesis in primates. Blood 74(7):154a (abstract #574) Zeidler C, Reiter A, Müller W, Riehm H, Welte K (1989): Korrektur der schweren kongenitalen Neutropenie und assoziierter klinischer Symptome bei Kindern mit rekombinantem humanen Granulozyten-Kolonien stimulierendem Faktor. Monatsschrift Kinderheilk 137(8):553 (abstract #268) Zeidler C, Reiter A, Riehm H, Müller W, Souza L, , Welte K (1989) Correction of severe congenital neutropenia in children with recombinant human granulocyte-colony stimulating factor (rhG-CSF). In: 7 International Congress of Immunology: 884 (abstract # 124-32) Emmendorffer A, Zeidler C, Welte K, Roesler J (1989) Altered function and surface marker expression of neutrophils induced by rhG-CSF treatment in severe congenital neutropenia. In: 7th International Congress of Immunology: 224 (abstract #40-6) Zeidler C, Reiter A, Müller W, Odenwald E, Souza L, Riehm H, Welte K (1989) Correction of severe congenital neutropenia and associated clinical symptoms in children with recombinant human granulocyte-colony stimulating factor (rhG-CSF). Eur J Pediatr 148(5):477 (abstract #1) Welte K, Zeidler C, Reiter A, Odenwald E, Menzel T, Bührer C, Feickert J, Müller W, Souza L, Riehm H (1988) Correction of neutropenia and associated clinical symptoms with rhG-CSF in children with severe congenital neutropenia. Blood 72(5):139a (abstract #465) Zeidler C, Krumwieh D, Seiler F, Welte K (1988) Effects of recombinant human interleukin-3 (rhIL-3) in chomotherapy induced myelosuppression in primates. Blood 72(5):140a (abstract #469)